Crohns DiseasePLEASE CLICK ON THE PINK BANNER ABOVE AND LEARN HOW TO GET YOUR MEDICINE FREE!! THAT IS ALSO MY SITE AND IS NOT A JOKE OR A SCAM.
Information and Support
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Click here for images of Crohn's Disease and Ulcerative Colitis
Nobody wants Crohn's Disease, and those who have it didn't do anything to
cause it. Not through diet, stress or adding alcohol or drugs does this happen.
Crohn's disease affects approximately 380,000 to 480,000 persons in the United States.
Since you are here, I feel it safe to assume you either have it or have a loved one with it. I hope you find these pages helpful.
This disease is believed by some scientists and researchers
to be caused by a glitch in the chromosome sequence, making it a potentially
inheireted condition. Other scientists and researchers believe it can be triggered by a
bacteria of some kind, and maybe they are both right. No one has been able to
establish a cause, and therefore there is no cure. There are 5 different types of Crohn's Disease, and it is very important that you know which type you have in order to be able to understand it and cope with it. Click here to reach the page on Types of Crohn's Disease.
Whatever the cause,
Crohn's disease is a terrible and life-altering illness to live with. I know, I have it. The type I have is Crohn's (Granulomatous) Colitis: Affects the colon only. Symptoms include diarrhea, severe abdominal pain, bloating, rectal bleeding, and disease around the anus (abscess, fistulas, ulcers)
I was 39 years old before I got sick, all my life I was always pretty healthy, and no one in my family has Crohns Disease so it is hard for me to figure the reason it has hit me, I am always asking "why me".
Please take a moment and complete this SURVEY or check out my BLOG and post a comment!!
For me, about 5 years before I was diagnosed with Crohn's Disease, the disease presented itself
with a single blister on my lower leg, which turned black and I got a systemic
infection. They told me it was a brown recluse spider bite. This happened 3 times within 2 years.
(Read My Story). Looking back,
I can now understand that it was the disease presenting itself as Pyoderma Gangrenosum, a blistering, disfiguring and potentially life threatening extraintestinal manifestation of Crohn's.
See Extraintestinal Manifestations for a complete explanation of Pyoderma Gangrenosum.
All of the information contained in these pages is fact, learned through
hundreds of hours of research and reading, by talking to a friend who is a doctor, another friend
who is an ARNP (Accredited Registered Nurse Practicioner), and many other friends
in the medical field like LPN's, RN's, Registered Dieticians, Nutritionists and Speech
Pathologists. Some info has come directly from the National Institutes of
Health (NIH) itself, or gleaned from databases on the internet.
I want to
know all about this ailment, what it is that has taken my life and turned it upside down, and I want to help myself if I can, and at the
same time if anyone else can benefit from all the work I have done, then
wonderful! That is the reason for this site.
Inflammatory bowel disease (IBD) is a general term that covers two disorders: ulcerative colitis and Crohn's disease. There is some evidence to suggest that they are part of a biologic continuum, but at this time they are considered to be distinct disorders with somewhat different treatment options. The basic distinctions are location and severity. It should be noted that as many as 10% of patients with IBD have findings and symptoms that match the criteria for both disorders, at least in the early stages (a situation called indeterminate colitis).
Current medical treatments
of Crohn's disease are expensive. It is most assuredly not a poor man's disease by any means.
In a study conducted in 1990 in the USA, it was estimated that the average
expenditure per year was $6,561 on every Crohn's disease patient in this
country. Fourteen years of inflation must place todays expenditure figure
as higher, since medical treatments have changed much since that time. We now
have a drug called Infliximab [ Remicade ], that was originally developed
for Rheumatoid Arthritis sufferers but has been discovered to be extremely
beneficial to Crohn's patients.
The total expenditure in the USA in 1990 was between $1,000,000,000 and
$1,200,000,000. Again, this must have increased, not only due to the
increased cost of treatment, but also to the increased number of sufferers
of the disease.
It is difficult to know how many people in the world suffer from Crohn's
disease. Based on
the epidemiology research from the United States, Crohn's disease affects approximately 380,000 to 480,000 persons in the United States.
The population of the United States is roughly
275 million people. Here is a table with anatomical percentages as well as a table determining the prevalence per capita:
distribution of Crohn's Disease
|Parts of bowel affected
||Percentage of cases
|Small bowel only
|Small bowel and colon
Crohn's disease occurs throughout the
world, estimated between 10 and 100 cases per 1,000,000 people. We can't seem to pin
it down any further because of those that go undiagnosed and misdiagnosed for many
years. Crohn's Diseaser occurs most frequently
among people of European origin, and is 3 to 8 times more common among Jews than among
non-Jews, and is more common among caucasions than other races. Although the disorder can begin
at any age, it most often occurs between 15 and 30 years of age. The typical Crohn's patient
is a young adult just beginning their life outside their parents home. There
be a family link of patients with Crohn's disease such that
20-30% of patients
with Crohn's disease have a family history of some sort of inflammatory
bowel disease or other gastrointestinal disorder. My mother had Diverticulitis
and died from stomach cancer in 1990 at the age of 61.
| Epidemiology of
inflammatory bowel disease
|Incidence (per 100,000)
|Prevalence (per 100,000)
||High in whites
||High in whites
||High in Jews
||High in Jews
||Slight female preponderance
||Slight female preponderance
The cause of inflammatory bowel disease has not yet been
determined. The abnormalities of T cells and/or macrophages and their
interaction still remains the most likely cause. In synthesizing existing
literature, one could propose the following sequence of pathological events
leading to the development of inflammatory bowel disease. The
gastrointestinal immune system becomes exposed to a mucosal antigen, perhaps
even an antigen normally present within the lumen -i.e., a bacterial
constituent of normal flora. However, on this occasion the antigen does not
evoke the typical antigen-specific suppressor T-cell activity, which would be
unresponsiveness. Rather, because of an antigen-specific immunoregulatory
defect, it evokes helper T-cell activity and sets in play an ongoing immune
response. This immune response as an epiphenomenon leads eventually to the
development of self-antigens and appearance of autoantibodies. Subsequently,
in an attempt to down-regulate the antigen-specific response,
antigen-nonspecific suppressor T cells appear. Initially, these
antigen-nonspecific suppressor T cells may prevent disease progression;
however, they are gradually depleted, leaving the unregulated antigen-specific
helper T-cell activity to predominate. This unregulated antigen-specific
immune response leads to the production of lymphokines, which stimulate
migration of inflammatory and cytolytic cells to the region. Through this
process the microscopic and gross morphological changes of inflammatory bowel
disease are manifest.
To see what your Crohn's Disease Activity Score is, check out the CDAI ( Crohn's Disease Activity Index)
On behalf of learning, and use as teaching tools for those of us who need to
know about our disease, I have tried to supply you with as much information as
I could find on all of the drugs, treatments and disorders associated with
Inflammatory Bowel Diseases, and specifically Crohn's Disease. I have tried to
blend all facts supported by research
and also from personal experiences of other IBD sufferers into one readable
website, and any and all information presented here is not entirely
from one source. Most information contained within these pages is found
in the public domain.
At times you may find information used from another site, and as with all
copyrighted materials you may find on these pages, I claim fair use under
sections 107 through 118 of the Copyright Act (title 17, U.S. Code).
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